overview on his Keynote lecture “Vitreous” to take place at SOE 2019 on 14/06/2019 @ 13:15 – 14:00
Vitreous is the largest but perhaps least understood part of the eye. Routine surgical removal of vitreous and apparent tolerance of the eye have resulted in the notion that vitreous has little importance. However, recent scientific discoveries have defined important roles for vitreous in ocular health and disease, enabling new strategies of therapy and prevention. For example, antioxidant properties in vitreous are now known to be important in maintaining lens clarity and probably in mitigating against other manifestations of oxidative stress, which may influence future approaches to vitrectomy surgery.
Dr. Sebag’s keynote lecture at SOE 2019 will review the molecular organization of vitreous and the significant structural changes that occur throughout life. Recent observations and investigations have identified how alterations in the vitreous body with myopia, aging, and disease result in vision loss. Indeed, it has recently been discovered that an event as seemingly simple as posterior vitreous detachment (PVD) can have profound impacts on vision, specifically degradation in contrast sensitivity function. Anomalous PVD will be presented as a unifying concept in better understanding vitreo-retinopathies, especially those that afflict the macula. New therapeutic paradigms will be discussed, with particular emphasis on pharmacologic vitreolysis and limited vitrectomy for vision degrading myodesopsia.